Socioeconomic status and the 25 × 25 risk factors as determinants of premature mortality: a multicohort study and meta-analysis of 1·7 million men and women.
Identifieur interne : 000357 ( PubMed/Checkpoint ); précédent : 000356; suivant : 000358Socioeconomic status and the 25 × 25 risk factors as determinants of premature mortality: a multicohort study and meta-analysis of 1·7 million men and women.
Auteurs : Silvia Stringhini [Suisse] ; Cristian Carmeli [Suisse] ; Markus Jokela [Finlande] ; Mauricio Avenda O [États-Unis] ; Peter Muennig [États-Unis] ; Florence Guida [Royaume-Uni] ; Fulvio Ricceri [Italie] ; Angelo D'Errico [Italie] ; Henrique Barros [Portugal] ; Murielle Bochud [Suisse] ; Marc Chadeau-Hyam [Royaume-Uni] ; Françoise Clavel-Chapelon [France] ; Giuseppe Costa [Italie] ; Cyrille Delpierre [France] ; Silvia Fraga [Portugal] ; Marcel Goldberg [France] ; Graham G. Giles [Australie] ; Vittorio Krogh [Italie] ; Michelle Kelly-Irving [France] ; Richard Layte [Irlande (pays)] ; Aurélie M. Lasserre [Suisse] ; Michael G. Marmot [Royaume-Uni] ; Martin Preisig [Suisse] ; Martin J. Shipley [Royaume-Uni] ; Peter Vollenweider [Suisse] ; Marie Zins [France] ; Ichiro Kawachi [États-Unis] ; Andrew Steptoe [Royaume-Uni] ; Johan P. Mackenbach [Pays-Bas] ; Paolo Vineis [Royaume-Uni] ; Mika Kivim Ki [Finlande]Source :
- Lancet (London, England) [ 1474-547X ] ; 2017.
Abstract
In 2011, WHO member states signed up to the 25 × 25 initiative, a plan to cut mortality due to non-communicable diseases by 25% by 2025. However, socioeconomic factors influencing non-communicable diseases have not been included in the plan. In this study, we aimed to compare the contribution of socioeconomic status to mortality and years-of-life-lost with that of the 25 × 25 conventional risk factors.
DOI: 10.1016/S0140-6736(16)32380-7
PubMed: 28159391
Affiliations:
- Australie, Finlande, France, Irlande (pays), Italie, Pays-Bas, Portugal, Royaume-Uni, Suisse, États-Unis
- Angleterre, Canton de Vaud, Grand Londres, Hollande-Méridionale, Lombardie, Midi-Pyrénées, Occitanie (région administrative), Piémont, Uusimaa, État de New York, Île-de-France
- Helsinki, Lausanne, Londres, Milan, New York, Paris, Rotterdam, Toulouse, Turin
- University College de Londres, Université Columbia, Université d'Helsinki
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Université Toulouse III Paul-Sabatier, UMR1027, Toulouse, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>INSERM, UMR1027, Toulouse, France; Université Toulouse III Paul-Sabatier, UMR1027, Toulouse</wicri:regionArea><placeName><region type="region">Occitanie (région administrative)</region><region type="old region">Midi-Pyrénées</region><settlement type="city">Toulouse</settlement></placeName></affiliation></author><author><name sortKey="Fraga, Silvia" sort="Fraga, Silvia" uniqKey="Fraga S" first="Silvia" last="Fraga">Silvia Fraga</name><affiliation wicri:level="1"><nlm:affiliation>EPIUnit-Institute of Public Health, University of Porto, Porto, Portugal.</nlm:affiliation><country xml:lang="fr">Portugal</country><wicri:regionArea>EPIUnit-Institute of Public Health, University of Porto, Porto</wicri:regionArea><wicri:noRegion>Porto</wicri:noRegion></affiliation></author><author><name sortKey="Goldberg, Marcel" sort="Goldberg, Marcel" uniqKey="Goldberg M" first="Marcel" last="Goldberg">Marcel Goldberg</name><affiliation wicri:level="3"><nlm:affiliation>Population-based Epidemiological Cohorts Unit, INSERM UMS 11, Villejuif, France; Paris Descartes University, Paris, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Population-based Epidemiological Cohorts Unit, INSERM UMS 11, Villejuif, France; Paris Descartes University, Paris</wicri:regionArea><placeName><region type="region">Île-de-France</region><region type="old region">Île-de-France</region><settlement type="city">Paris</settlement></placeName></affiliation></author><author><name sortKey="Giles, Graham G" sort="Giles, Graham G" uniqKey="Giles G" first="Graham G" last="Giles">Graham G. 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Shipley</name><affiliation wicri:level="4"><nlm:affiliation>University College London, Department of Epidemiology and Public Health, London, UK.</nlm:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>University College London, Department of Epidemiology and Public Health, London</wicri:regionArea><placeName><settlement type="city">Londres</settlement><region type="country">Angleterre</region><region type="région" nuts="1">Grand Londres</region><settlement type="city">Londres</settlement></placeName><orgName type="university">University College de Londres</orgName></affiliation></author><author><name sortKey="Vollenweider, Peter" sort="Vollenweider, Peter" uniqKey="Vollenweider P" first="Peter" last="Vollenweider">Peter Vollenweider</name><affiliation wicri:level="3"><nlm:affiliation>Institute of Social and Preventive Medicine and Departments of Psychiatry and Internal Medicine, Lausanne University Hospital, Lausanne, Switzerland.</nlm:affiliation><country xml:lang="fr">Suisse</country><wicri:regionArea>Institute of Social and Preventive Medicine and Departments of Psychiatry and Internal Medicine, Lausanne University Hospital, Lausanne</wicri:regionArea><placeName><settlement type="city">Lausanne</settlement><region nuts="3" type="region">Canton de Vaud</region></placeName></affiliation></author><author><name sortKey="Zins, Marie" sort="Zins, Marie" uniqKey="Zins M" first="Marie" last="Zins">Marie Zins</name><affiliation wicri:level="3"><nlm:affiliation>Population-based Epidemiological Cohorts Unit, INSERM UMS 11, Villejuif, France; Paris Descartes University, Paris, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Population-based Epidemiological Cohorts Unit, INSERM UMS 11, Villejuif, France; Paris Descartes University, Paris</wicri:regionArea><placeName><region type="region">Île-de-France</region><region type="old region">Île-de-France</region><settlement type="city">Paris</settlement></placeName></affiliation></author><author><name sortKey="Kawachi, Ichiro" sort="Kawachi, Ichiro" uniqKey="Kawachi I" first="Ichiro" last="Kawachi">Ichiro Kawachi</name><affiliation wicri:level="1"><nlm:affiliation>Harvard T H Chan School of Public Health, Boston MA, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Harvard T H Chan School of Public Health, Boston MA</wicri:regionArea><wicri:noRegion>Boston MA</wicri:noRegion></affiliation></author><author><name sortKey="Steptoe, Andrew" sort="Steptoe, Andrew" uniqKey="Steptoe A" first="Andrew" last="Steptoe">Andrew Steptoe</name><affiliation wicri:level="4"><nlm:affiliation>University College London, Department of Epidemiology and Public Health, London, UK.</nlm:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>University College London, Department of Epidemiology and Public Health, London</wicri:regionArea><placeName><settlement type="city">Londres</settlement><region type="country">Angleterre</region><region type="région" nuts="1">Grand Londres</region><settlement type="city">Londres</settlement></placeName><orgName type="university">University College de Londres</orgName></affiliation></author><author><name sortKey="Mackenbach, Johan P" sort="Mackenbach, Johan P" uniqKey="Mackenbach J" first="Johan P" last="Mackenbach">Johan P. Mackenbach</name><affiliation wicri:level="3"><nlm:affiliation>Department of Public Health, Erasmus University Medical Center, Rotterdam, Netherlands.</nlm:affiliation><country xml:lang="fr">Pays-Bas</country><wicri:regionArea>Department of Public Health, Erasmus University Medical Center, Rotterdam</wicri:regionArea><placeName><settlement type="city">Rotterdam</settlement><region nuts="2" type="province">Hollande-Méridionale</region></placeName></affiliation></author><author><name sortKey="Vineis, Paolo" sort="Vineis, Paolo" uniqKey="Vineis P" first="Paolo" last="Vineis">Paolo Vineis</name><affiliation wicri:level="3"><nlm:affiliation>MRC-PHE Centre for Environment and Health, School of Public Health, Department of Epidemiology and Biostatistics, Imperial College London, London, UK.</nlm:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>MRC-PHE Centre for Environment and Health, School of Public Health, Department of Epidemiology and Biostatistics, Imperial College London, London</wicri:regionArea><placeName><settlement type="city">Londres</settlement><region type="country">Angleterre</region><region type="région" nuts="1">Grand Londres</region></placeName></affiliation></author><author><name sortKey="Kivim Ki, Mika" sort="Kivim Ki, Mika" uniqKey="Kivim Ki M" first="Mika" last="Kivim Ki">Mika Kivim Ki</name><affiliation wicri:level="4"><nlm:affiliation>University College London, Department of Epidemiology and Public Health, London, UK; Clinicum, Faculty of Medicine, University of Helsinki, Finland.</nlm:affiliation><country xml:lang="fr">Finlande</country><wicri:regionArea>University College London, Department of Epidemiology and Public Health, London, UK; Clinicum, Faculty of Medicine, University of Helsinki</wicri:regionArea><placeName><settlement type="city">Helsinki</settlement><region type="région" nuts="2">Uusimaa</region></placeName><orgName type="university">Université d'Helsinki</orgName></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="2017">2017</date><idno type="RBID">pubmed:28159391</idno><idno type="pmid">28159391</idno><idno type="doi">10.1016/S0140-6736(16)32380-7</idno><idno type="wicri:Area/PubMed/Corpus">000F46</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Corpus" wicri:corpus="PubMed">000F46</idno><idno type="wicri:Area/PubMed/Curation">000F43</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Curation">000F43</idno><idno type="wicri:Area/PubMed/Checkpoint">000F43</idno><idno type="wicri:explorRef" wicri:stream="Checkpoint" wicri:step="PubMed">000F43</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en">Socioeconomic status and the 25 × 25 risk factors as determinants of premature mortality: a multicohort study and meta-analysis of 1·7 million men and women.</title><author><name sortKey="Stringhini, Silvia" sort="Stringhini, Silvia" uniqKey="Stringhini S" first="Silvia" last="Stringhini">Silvia Stringhini</name><affiliation wicri:level="3"><nlm:affiliation>Institute of Social and Preventive Medicine and Departments of Psychiatry and Internal Medicine, Lausanne University Hospital, Lausanne, Switzerland. Electronic address: silvia.stringhini@chuv.ch.</nlm:affiliation><country xml:lang="fr">Suisse</country><wicri:regionArea>Institute of Social and Preventive Medicine and Departments of Psychiatry and Internal Medicine, Lausanne University Hospital, Lausanne</wicri:regionArea><placeName><settlement type="city">Lausanne</settlement><region nuts="3" type="region">Canton de Vaud</region></placeName></affiliation></author><author><name sortKey="Carmeli, Cristian" sort="Carmeli, Cristian" uniqKey="Carmeli C" first="Cristian" last="Carmeli">Cristian Carmeli</name><affiliation wicri:level="3"><nlm:affiliation>Institute of Social and Preventive Medicine and Departments of Psychiatry and Internal Medicine, Lausanne University Hospital, Lausanne, Switzerland.</nlm:affiliation><country xml:lang="fr">Suisse</country><wicri:regionArea>Institute of Social and Preventive Medicine and Departments of Psychiatry and Internal Medicine, Lausanne University Hospital, Lausanne</wicri:regionArea><placeName><settlement type="city">Lausanne</settlement><region nuts="3" type="region">Canton de Vaud</region></placeName></affiliation></author><author><name sortKey="Jokela, Markus" sort="Jokela, Markus" uniqKey="Jokela M" first="Markus" last="Jokela">Markus Jokela</name><affiliation wicri:level="4"><nlm:affiliation>Institute of Behavioural Sciences, University of Helsinki, Helsinki, Finland.</nlm:affiliation><country xml:lang="fr">Finlande</country><wicri:regionArea>Institute of Behavioural Sciences, University of Helsinki, Helsinki</wicri:regionArea><orgName type="university">Université d'Helsinki</orgName><placeName><settlement type="city">Helsinki</settlement><region type="région" nuts="2">Uusimaa</region></placeName></affiliation></author><author><name sortKey="Avenda O, Mauricio" sort="Avenda O, Mauricio" uniqKey="Avenda O M" first="Mauricio" last="Avenda O">Mauricio Avenda O</name><affiliation wicri:level="1"><nlm:affiliation>Department of Global Health and Social Medicine, King's College London, London, UK; Harvard T H Chan School of Public Health, Boston MA, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Global Health and Social Medicine, King's College London, London, UK; Harvard T H Chan School of Public Health, Boston MA</wicri:regionArea><wicri:noRegion>Boston MA</wicri:noRegion></affiliation></author><author><name sortKey="Muennig, Peter" sort="Muennig, Peter" uniqKey="Muennig P" first="Peter" last="Muennig">Peter Muennig</name><affiliation wicri:level="4"><nlm:affiliation>Global Research Analytics for Population Health, Health Policy and Management, Columbia University, New York, NY, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Global Research Analytics for Population Health, Health Policy and Management, Columbia University, New York, NY</wicri:regionArea><placeName><region type="state">État de New York</region><settlement type="city">New York</settlement></placeName><orgName type="university">Université Columbia</orgName></affiliation></author><author><name sortKey="Guida, Florence" sort="Guida, Florence" uniqKey="Guida F" first="Florence" last="Guida">Florence Guida</name><affiliation wicri:level="3"><nlm:affiliation>MRC-PHE Centre for Environment and Health, School of Public Health, Department of Epidemiology and Biostatistics, Imperial College London, London, UK.</nlm:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>MRC-PHE Centre for Environment and Health, School of Public Health, Department of Epidemiology and Biostatistics, Imperial College London, London</wicri:regionArea><placeName><settlement type="city">Londres</settlement><region type="country">Angleterre</region><region type="région" nuts="1">Grand Londres</region></placeName></affiliation></author><author><name sortKey="Ricceri, Fulvio" sort="Ricceri, Fulvio" uniqKey="Ricceri F" first="Fulvio" last="Ricceri">Fulvio Ricceri</name><affiliation wicri:level="1"><nlm:affiliation>Epidemiology Unit, ASL TO3 Piedmont Region, Grugliasco, Italy.</nlm:affiliation><country xml:lang="fr">Italie</country><wicri:regionArea>Epidemiology Unit, ASL TO3 Piedmont Region, Grugliasco</wicri:regionArea><wicri:noRegion>Grugliasco</wicri:noRegion></affiliation></author><author><name sortKey="D Errico, Angelo" sort="D Errico, Angelo" uniqKey="D Errico A" first="Angelo" last="D'Errico">Angelo D'Errico</name><affiliation wicri:level="1"><nlm:affiliation>Epidemiology Unit, ASL TO3 Piedmont Region, Grugliasco, Italy.</nlm:affiliation><country xml:lang="fr">Italie</country><wicri:regionArea>Epidemiology Unit, ASL TO3 Piedmont Region, Grugliasco</wicri:regionArea><wicri:noRegion>Grugliasco</wicri:noRegion></affiliation></author><author><name sortKey="Barros, Henrique" sort="Barros, Henrique" uniqKey="Barros H" first="Henrique" last="Barros">Henrique Barros</name><affiliation wicri:level="1"><nlm:affiliation>EPIUnit-Institute of Public Health, University of Porto, Porto, Portugal; Department of Clinical Epidemiology, Predictive Medicine and Public Health, University of Porto Medical School, Porto, Portugal.</nlm:affiliation><country xml:lang="fr">Portugal</country><wicri:regionArea>EPIUnit-Institute of Public Health, University of Porto, Porto, Portugal; Department of Clinical Epidemiology, Predictive Medicine and Public Health, University of Porto Medical School, Porto</wicri:regionArea><wicri:noRegion>Porto</wicri:noRegion></affiliation></author><author><name sortKey="Bochud, Murielle" sort="Bochud, Murielle" uniqKey="Bochud M" first="Murielle" last="Bochud">Murielle Bochud</name><affiliation wicri:level="3"><nlm:affiliation>Institute of Social and Preventive Medicine and Departments of Psychiatry and Internal Medicine, Lausanne University Hospital, Lausanne, Switzerland.</nlm:affiliation><country xml:lang="fr">Suisse</country><wicri:regionArea>Institute of Social and Preventive Medicine and Departments of Psychiatry and Internal Medicine, Lausanne University Hospital, Lausanne</wicri:regionArea><placeName><settlement type="city">Lausanne</settlement><region nuts="3" type="region">Canton de Vaud</region></placeName></affiliation></author><author><name sortKey="Chadeau Hyam, Marc" sort="Chadeau Hyam, Marc" uniqKey="Chadeau Hyam M" first="Marc" last="Chadeau-Hyam">Marc Chadeau-Hyam</name><affiliation wicri:level="3"><nlm:affiliation>MRC-PHE Centre for Environment and Health, School of Public Health, Department of Epidemiology and Biostatistics, Imperial College London, London, UK.</nlm:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>MRC-PHE Centre for Environment and Health, School of Public Health, Department of Epidemiology and Biostatistics, Imperial College London, London</wicri:regionArea><placeName><settlement type="city">Londres</settlement><region type="country">Angleterre</region><region type="région" nuts="1">Grand Londres</region></placeName></affiliation></author><author><name sortKey="Clavel Chapelon, Francoise" sort="Clavel Chapelon, Francoise" uniqKey="Clavel Chapelon F" first="Françoise" last="Clavel-Chapelon">Françoise Clavel-Chapelon</name><affiliation wicri:level="1"><nlm:affiliation>Center for Research in Epidemiology and Population Health, INSERM U1018, Villejuif, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Center for Research in Epidemiology and Population Health, INSERM U1018, Villejuif</wicri:regionArea><wicri:noRegion>Villejuif</wicri:noRegion><wicri:noRegion>Villejuif</wicri:noRegion></affiliation></author><author><name sortKey="Costa, Giuseppe" sort="Costa, Giuseppe" uniqKey="Costa G" first="Giuseppe" last="Costa">Giuseppe Costa</name><affiliation wicri:level="3"><nlm:affiliation>Department of Biological and Clinical Sciences, Universtiy of Turin, Turin, Italy.</nlm:affiliation><country xml:lang="fr">Italie</country><wicri:regionArea>Department of Biological and Clinical Sciences, Universtiy of Turin, Turin</wicri:regionArea><placeName><settlement type="city">Turin</settlement><region type="région" nuts="2">Piémont</region></placeName></affiliation></author><author><name sortKey="Delpierre, Cyrille" sort="Delpierre, Cyrille" uniqKey="Delpierre C" first="Cyrille" last="Delpierre">Cyrille Delpierre</name><affiliation wicri:level="3"><nlm:affiliation>INSERM, UMR1027, Toulouse, France; Université Toulouse III Paul-Sabatier, UMR1027, Toulouse, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>INSERM, UMR1027, Toulouse, France; Université Toulouse III Paul-Sabatier, UMR1027, Toulouse</wicri:regionArea><placeName><region type="region">Occitanie (région administrative)</region><region type="old region">Midi-Pyrénées</region><settlement type="city">Toulouse</settlement></placeName></affiliation></author><author><name sortKey="Fraga, Silvia" sort="Fraga, Silvia" uniqKey="Fraga S" first="Silvia" last="Fraga">Silvia Fraga</name><affiliation wicri:level="1"><nlm:affiliation>EPIUnit-Institute of Public Health, University of Porto, Porto, Portugal.</nlm:affiliation><country xml:lang="fr">Portugal</country><wicri:regionArea>EPIUnit-Institute of Public Health, University of Porto, Porto</wicri:regionArea><wicri:noRegion>Porto</wicri:noRegion></affiliation></author><author><name sortKey="Goldberg, Marcel" sort="Goldberg, Marcel" uniqKey="Goldberg M" first="Marcel" last="Goldberg">Marcel Goldberg</name><affiliation wicri:level="3"><nlm:affiliation>Population-based Epidemiological Cohorts Unit, INSERM UMS 11, Villejuif, France; Paris Descartes University, Paris, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Population-based Epidemiological Cohorts Unit, INSERM UMS 11, Villejuif, France; Paris Descartes University, Paris</wicri:regionArea><placeName><region type="region">Île-de-France</region><region type="old region">Île-de-France</region><settlement type="city">Paris</settlement></placeName></affiliation></author><author><name sortKey="Giles, Graham G" sort="Giles, Graham G" uniqKey="Giles G" first="Graham G" last="Giles">Graham G. Giles</name><affiliation wicri:level="1"><nlm:affiliation>Cancer Epidemiology Centre, Cancer Council Victoria, Melbourne, VIC, Australia.</nlm:affiliation><country xml:lang="fr">Australie</country><wicri:regionArea>Cancer Epidemiology Centre, Cancer Council Victoria, Melbourne, VIC</wicri:regionArea><wicri:noRegion>VIC</wicri:noRegion></affiliation></author><author><name sortKey="Krogh, Vittorio" sort="Krogh, Vittorio" uniqKey="Krogh V" first="Vittorio" last="Krogh">Vittorio Krogh</name><affiliation wicri:level="3"><nlm:affiliation>Epidemiology and Prevention Unit, Fondazione IRCCS Istituto Nazionale dei Tumori, Milan, Italy.</nlm:affiliation><country xml:lang="fr">Italie</country><wicri:regionArea>Epidemiology and Prevention Unit, Fondazione IRCCS Istituto Nazionale dei Tumori, Milan</wicri:regionArea><placeName><settlement type="city">Milan</settlement><region nuts="2">Lombardie</region></placeName></affiliation></author><author><name sortKey="Kelly Irving, Michelle" sort="Kelly Irving, Michelle" uniqKey="Kelly Irving M" first="Michelle" last="Kelly-Irving">Michelle Kelly-Irving</name><affiliation wicri:level="3"><nlm:affiliation>INSERM, UMR1027, Toulouse, France; Université Toulouse III Paul-Sabatier, UMR1027, Toulouse, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>INSERM, UMR1027, Toulouse, France; Université Toulouse III Paul-Sabatier, UMR1027, Toulouse</wicri:regionArea><placeName><region type="region">Occitanie (région administrative)</region><region type="old region">Midi-Pyrénées</region><settlement type="city">Toulouse</settlement></placeName></affiliation></author><author><name sortKey="Layte, Richard" sort="Layte, Richard" uniqKey="Layte R" first="Richard" last="Layte">Richard Layte</name><affiliation wicri:level="1"><nlm:affiliation>Department of Sociology, Trinity College Dublin, Dublin, Ireland.</nlm:affiliation><country xml:lang="fr">Irlande (pays)</country><wicri:regionArea>Department of Sociology, Trinity College Dublin, Dublin</wicri:regionArea><wicri:noRegion>Dublin</wicri:noRegion></affiliation></author><author><name sortKey="Lasserre, Aurelie M" sort="Lasserre, Aurelie M" uniqKey="Lasserre A" first="Aurélie M" last="Lasserre">Aurélie M. Lasserre</name><affiliation wicri:level="3"><nlm:affiliation>Institute of Social and Preventive Medicine and Departments of Psychiatry and Internal Medicine, Lausanne University Hospital, Lausanne, Switzerland.</nlm:affiliation><country xml:lang="fr">Suisse</country><wicri:regionArea>Institute of Social and Preventive Medicine and Departments of Psychiatry and Internal Medicine, Lausanne University Hospital, Lausanne</wicri:regionArea><placeName><settlement type="city">Lausanne</settlement><region nuts="3" type="region">Canton de Vaud</region></placeName></affiliation></author><author><name sortKey="Marmot, Michael G" sort="Marmot, Michael G" uniqKey="Marmot M" first="Michael G" last="Marmot">Michael G. Marmot</name><affiliation wicri:level="4"><nlm:affiliation>University College London, Department of Epidemiology and Public Health, London, UK.</nlm:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>University College London, Department of Epidemiology and Public Health, London</wicri:regionArea><placeName><settlement type="city">Londres</settlement><region type="country">Angleterre</region><region type="région" nuts="1">Grand Londres</region><settlement type="city">Londres</settlement></placeName><orgName type="university">University College de Londres</orgName></affiliation></author><author><name sortKey="Preisig, Martin" sort="Preisig, Martin" uniqKey="Preisig M" first="Martin" last="Preisig">Martin Preisig</name><affiliation wicri:level="3"><nlm:affiliation>Institute of Social and Preventive Medicine and Departments of Psychiatry and Internal Medicine, Lausanne University Hospital, Lausanne, Switzerland.</nlm:affiliation><country xml:lang="fr">Suisse</country><wicri:regionArea>Institute of Social and Preventive Medicine and Departments of Psychiatry and Internal Medicine, Lausanne University Hospital, Lausanne</wicri:regionArea><placeName><settlement type="city">Lausanne</settlement><region nuts="3" type="region">Canton de Vaud</region></placeName></affiliation></author><author><name sortKey="Shipley, Martin J" sort="Shipley, Martin J" uniqKey="Shipley M" first="Martin J" last="Shipley">Martin J. Shipley</name><affiliation wicri:level="4"><nlm:affiliation>University College London, Department of Epidemiology and Public Health, London, UK.</nlm:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>University College London, Department of Epidemiology and Public Health, London</wicri:regionArea><placeName><settlement type="city">Londres</settlement><region type="country">Angleterre</region><region type="région" nuts="1">Grand Londres</region><settlement type="city">Londres</settlement></placeName><orgName type="university">University College de Londres</orgName></affiliation></author><author><name sortKey="Vollenweider, Peter" sort="Vollenweider, Peter" uniqKey="Vollenweider P" first="Peter" last="Vollenweider">Peter Vollenweider</name><affiliation wicri:level="3"><nlm:affiliation>Institute of Social and Preventive Medicine and Departments of Psychiatry and Internal Medicine, Lausanne University Hospital, Lausanne, Switzerland.</nlm:affiliation><country xml:lang="fr">Suisse</country><wicri:regionArea>Institute of Social and Preventive Medicine and Departments of Psychiatry and Internal Medicine, Lausanne University Hospital, Lausanne</wicri:regionArea><placeName><settlement type="city">Lausanne</settlement><region nuts="3" type="region">Canton de Vaud</region></placeName></affiliation></author><author><name sortKey="Zins, Marie" sort="Zins, Marie" uniqKey="Zins M" first="Marie" last="Zins">Marie Zins</name><affiliation wicri:level="3"><nlm:affiliation>Population-based Epidemiological Cohorts Unit, INSERM UMS 11, Villejuif, France; Paris Descartes University, Paris, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Population-based Epidemiological Cohorts Unit, INSERM UMS 11, Villejuif, France; Paris Descartes University, Paris</wicri:regionArea><placeName><region type="region">Île-de-France</region><region type="old region">Île-de-France</region><settlement type="city">Paris</settlement></placeName></affiliation></author><author><name sortKey="Kawachi, Ichiro" sort="Kawachi, Ichiro" uniqKey="Kawachi I" first="Ichiro" last="Kawachi">Ichiro Kawachi</name><affiliation wicri:level="1"><nlm:affiliation>Harvard T H Chan School of Public Health, Boston MA, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Harvard T H Chan School of Public Health, Boston MA</wicri:regionArea><wicri:noRegion>Boston MA</wicri:noRegion></affiliation></author><author><name sortKey="Steptoe, Andrew" sort="Steptoe, Andrew" uniqKey="Steptoe A" first="Andrew" last="Steptoe">Andrew Steptoe</name><affiliation wicri:level="4"><nlm:affiliation>University College London, Department of Epidemiology and Public Health, London, UK.</nlm:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>University College London, Department of Epidemiology and Public Health, London</wicri:regionArea><placeName><settlement type="city">Londres</settlement><region type="country">Angleterre</region><region type="région" nuts="1">Grand Londres</region><settlement type="city">Londres</settlement></placeName><orgName type="university">University College de Londres</orgName></affiliation></author><author><name sortKey="Mackenbach, Johan P" sort="Mackenbach, Johan P" uniqKey="Mackenbach J" first="Johan P" last="Mackenbach">Johan P. Mackenbach</name><affiliation wicri:level="3"><nlm:affiliation>Department of Public Health, Erasmus University Medical Center, Rotterdam, Netherlands.</nlm:affiliation><country xml:lang="fr">Pays-Bas</country><wicri:regionArea>Department of Public Health, Erasmus University Medical Center, Rotterdam</wicri:regionArea><placeName><settlement type="city">Rotterdam</settlement><region nuts="2" type="province">Hollande-Méridionale</region></placeName></affiliation></author><author><name sortKey="Vineis, Paolo" sort="Vineis, Paolo" uniqKey="Vineis P" first="Paolo" last="Vineis">Paolo Vineis</name><affiliation wicri:level="3"><nlm:affiliation>MRC-PHE Centre for Environment and Health, School of Public Health, Department of Epidemiology and Biostatistics, Imperial College London, London, UK.</nlm:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>MRC-PHE Centre for Environment and Health, School of Public Health, Department of Epidemiology and Biostatistics, Imperial College London, London</wicri:regionArea><placeName><settlement type="city">Londres</settlement><region type="country">Angleterre</region><region type="région" nuts="1">Grand Londres</region></placeName></affiliation></author><author><name sortKey="Kivim Ki, Mika" sort="Kivim Ki, Mika" uniqKey="Kivim Ki M" first="Mika" last="Kivim Ki">Mika Kivim Ki</name><affiliation wicri:level="4"><nlm:affiliation>University College London, Department of Epidemiology and Public Health, London, UK; Clinicum, Faculty of Medicine, University of Helsinki, Finland.</nlm:affiliation><country xml:lang="fr">Finlande</country><wicri:regionArea>University College London, Department of Epidemiology and Public Health, London, UK; Clinicum, Faculty of Medicine, University of Helsinki</wicri:regionArea><placeName><settlement type="city">Helsinki</settlement><region type="région" nuts="2">Uusimaa</region></placeName><orgName type="university">Université d'Helsinki</orgName></affiliation></author></analytic><series><title level="j">Lancet (London, England)</title><idno type="eISSN">1474-547X</idno><imprint><date when="2017" type="published">2017</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">In 2011, WHO member states signed up to the 25 × 25 initiative, a plan to cut mortality due to non-communicable diseases by 25% by 2025. However, socioeconomic factors influencing non-communicable diseases have not been included in the plan. In this study, we aimed to compare the contribution of socioeconomic status to mortality and years-of-life-lost with that of the 25 × 25 conventional risk factors.</div></front></TEI><pubmed><MedlineCitation Status="In-Data-Review" Owner="NLM"><PMID Version="1">28159391</PMID><DateCreated><Year>2017</Year><Month>02</Month><Day>04</Day></DateCreated><DateRevised><Year>2017</Year><Month>09</Month><Day>22</Day></DateRevised><Article PubModel="Print-Electronic"><Journal><ISSN IssnType="Electronic">1474-547X</ISSN><JournalIssue CitedMedium="Internet"><Volume>389</Volume><Issue>10075</Issue><PubDate><Year>2017</Year><Month>Mar</Month><Day>25</Day></PubDate></JournalIssue><Title>Lancet (London, England)</Title><ISOAbbreviation>Lancet</ISOAbbreviation></Journal><ArticleTitle>Socioeconomic status and the 25 × 25 risk factors as determinants of premature mortality: a multicohort study and meta-analysis of 1·7 million men and women.</ArticleTitle><Pagination><MedlinePgn>1229-1237</MedlinePgn></Pagination><ELocationID EIdType="pii" ValidYN="Y">S0140-6736(16)32380-7</ELocationID><ELocationID EIdType="doi" ValidYN="Y">10.1016/S0140-6736(16)32380-7</ELocationID><Abstract><AbstractText Label="BACKGROUND" NlmCategory="BACKGROUND">In 2011, WHO member states signed up to the 25 × 25 initiative, a plan to cut mortality due to non-communicable diseases by 25% by 2025. However, socioeconomic factors influencing non-communicable diseases have not been included in the plan. In this study, we aimed to compare the contribution of socioeconomic status to mortality and years-of-life-lost with that of the 25 × 25 conventional risk factors.</AbstractText><AbstractText Label="METHODS" NlmCategory="METHODS">We did a multicohort study and meta-analysis with individual-level data from 48 independent prospective cohort studies with information about socioeconomic status, indexed by occupational position, 25 × 25 risk factors (high alcohol intake, physical inactivity, current smoking, hypertension, diabetes, and obesity), and mortality, for a total population of 1 751 479 (54% women) from seven high-income WHO member countries. We estimated the association of socioeconomic status and the 25 × 25 risk factors with all-cause mortality and cause-specific mortality by calculating minimally adjusted and mutually adjusted hazard ratios [HR] and 95% CIs. We also estimated the population attributable fraction and the years of life lost due to suboptimal risk factors.</AbstractText><AbstractText Label="FINDINGS" NlmCategory="RESULTS">During 26·6 million person-years at risk (mean follow-up 13·3 years [SD 6·4 years]), 310 277 participants died. HR for the 25 × 25 risk factors and mortality varied between 1·04 (95% CI 0·98-1·11) for obesity in men and 2 ·17 (2·06-2·29) for current smoking in men. Participants with low socioeconomic status had greater mortality compared with those with high socioeconomic status (HR 1·42, 95% CI 1·38-1·45 for men; 1·34, 1·28-1·39 for women); this association remained significant in mutually adjusted models that included the 25 × 25 factors (HR 1·26, 1·21-1·32, men and women combined). The population attributable fraction was highest for smoking, followed by physical inactivity then socioeconomic status. Low socioeconomic status was associated with a 2·1-year reduction in life expectancy between ages 40 and 85 years, the corresponding years-of-life-lost were 0·5 years for high alcohol intake, 0·7 years for obesity, 3·9 years for diabetes, 1·6 years for hypertension, 2·4 years for physical inactivity, and 4·8 years for current smoking.</AbstractText><AbstractText Label="INTERPRETATION" NlmCategory="CONCLUSIONS">Socioeconomic circumstances, in addition to the 25 × 25 factors, should be targeted by local and global health strategies and health risk surveillance to reduce mortality.</AbstractText><AbstractText Label="FUNDING" NlmCategory="BACKGROUND">European Commission, Swiss State Secretariat for Education, Swiss National Science Foundation, the Medical Research Council, NordForsk, Portuguese Foundation for Science and Technology.</AbstractText><CopyrightInformation>Copyright © 2017 The Author(s). Published by Elsevier Ltd. This is an Open Access article under the CC BY license. Published by Elsevier Ltd.. All rights reserved.</CopyrightInformation></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Stringhini</LastName><ForeName>Silvia</ForeName><Initials>S</Initials><AffiliationInfo><Affiliation>Institute of Social and Preventive Medicine and Departments of Psychiatry and Internal Medicine, Lausanne University Hospital, Lausanne, Switzerland. Electronic address: silvia.stringhini@chuv.ch.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Carmeli</LastName><ForeName>Cristian</ForeName><Initials>C</Initials><AffiliationInfo><Affiliation>Institute of Social and Preventive Medicine and Departments of Psychiatry and Internal Medicine, Lausanne University Hospital, Lausanne, Switzerland.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Jokela</LastName><ForeName>Markus</ForeName><Initials>M</Initials><AffiliationInfo><Affiliation>Institute of Behavioural Sciences, University of Helsinki, Helsinki, Finland.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Avendaño</LastName><ForeName>Mauricio</ForeName><Initials>M</Initials><AffiliationInfo><Affiliation>Department of Global Health and Social Medicine, King's College London, London, UK; Harvard T H Chan School of Public Health, Boston MA, USA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Muennig</LastName><ForeName>Peter</ForeName><Initials>P</Initials><AffiliationInfo><Affiliation>Global Research Analytics for Population Health, Health Policy and Management, Columbia University, New York, NY, USA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Guida</LastName><ForeName>Florence</ForeName><Initials>F</Initials><AffiliationInfo><Affiliation>MRC-PHE Centre for Environment and Health, School of Public Health, Department of Epidemiology and Biostatistics, Imperial College London, London, UK.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Ricceri</LastName><ForeName>Fulvio</ForeName><Initials>F</Initials><AffiliationInfo><Affiliation>Epidemiology Unit, ASL TO3 Piedmont Region, Grugliasco, Italy.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>d'Errico</LastName><ForeName>Angelo</ForeName><Initials>A</Initials><AffiliationInfo><Affiliation>Epidemiology Unit, ASL TO3 Piedmont Region, Grugliasco, Italy.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Barros</LastName><ForeName>Henrique</ForeName><Initials>H</Initials><AffiliationInfo><Affiliation>EPIUnit-Institute of Public Health, University of Porto, Porto, Portugal; Department of Clinical Epidemiology, Predictive Medicine and Public Health, University of Porto Medical School, Porto, Portugal.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Bochud</LastName><ForeName>Murielle</ForeName><Initials>M</Initials><AffiliationInfo><Affiliation>Institute of Social and Preventive Medicine and Departments of Psychiatry and Internal Medicine, Lausanne University Hospital, Lausanne, Switzerland.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Chadeau-Hyam</LastName><ForeName>Marc</ForeName><Initials>M</Initials><AffiliationInfo><Affiliation>MRC-PHE Centre for Environment and Health, School of Public Health, Department of Epidemiology and Biostatistics, Imperial College London, London, UK.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Clavel-Chapelon</LastName><ForeName>Françoise</ForeName><Initials>F</Initials><AffiliationInfo><Affiliation>Center for Research in Epidemiology and Population Health, INSERM U1018, Villejuif, France.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Costa</LastName><ForeName>Giuseppe</ForeName><Initials>G</Initials><AffiliationInfo><Affiliation>Department of Biological and Clinical Sciences, Universtiy of Turin, Turin, Italy.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Delpierre</LastName><ForeName>Cyrille</ForeName><Initials>C</Initials><AffiliationInfo><Affiliation>INSERM, UMR1027, Toulouse, France; Université Toulouse III Paul-Sabatier, UMR1027, Toulouse, France.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Fraga</LastName><ForeName>Silvia</ForeName><Initials>S</Initials><AffiliationInfo><Affiliation>EPIUnit-Institute of Public Health, University of Porto, Porto, Portugal.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Goldberg</LastName><ForeName>Marcel</ForeName><Initials>M</Initials><AffiliationInfo><Affiliation>Population-based Epidemiological Cohorts Unit, INSERM UMS 11, Villejuif, France; Paris Descartes University, Paris, France.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Giles</LastName><ForeName>Graham G</ForeName><Initials>GG</Initials><AffiliationInfo><Affiliation>Cancer Epidemiology Centre, Cancer Council Victoria, Melbourne, VIC, Australia.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Krogh</LastName><ForeName>Vittorio</ForeName><Initials>V</Initials><AffiliationInfo><Affiliation>Epidemiology and Prevention Unit, Fondazione IRCCS Istituto Nazionale dei Tumori, Milan, Italy.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Kelly-Irving</LastName><ForeName>Michelle</ForeName><Initials>M</Initials><AffiliationInfo><Affiliation>INSERM, UMR1027, Toulouse, France; Université Toulouse III Paul-Sabatier, UMR1027, Toulouse, France.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Layte</LastName><ForeName>Richard</ForeName><Initials>R</Initials><AffiliationInfo><Affiliation>Department of Sociology, Trinity College Dublin, Dublin, Ireland.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Lasserre</LastName><ForeName>Aurélie M</ForeName><Initials>AM</Initials><AffiliationInfo><Affiliation>Institute of Social and Preventive Medicine and Departments of Psychiatry and Internal Medicine, Lausanne University Hospital, Lausanne, Switzerland.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Marmot</LastName><ForeName>Michael G</ForeName><Initials>MG</Initials><AffiliationInfo><Affiliation>University College London, Department of Epidemiology and Public Health, London, UK.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Preisig</LastName><ForeName>Martin</ForeName><Initials>M</Initials><AffiliationInfo><Affiliation>Institute of Social and Preventive Medicine and Departments of Psychiatry and Internal Medicine, Lausanne University Hospital, Lausanne, Switzerland.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Shipley</LastName><ForeName>Martin J</ForeName><Initials>MJ</Initials><AffiliationInfo><Affiliation>University College London, Department of Epidemiology and Public Health, London, UK.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Vollenweider</LastName><ForeName>Peter</ForeName><Initials>P</Initials><AffiliationInfo><Affiliation>Institute of Social and Preventive Medicine and Departments of Psychiatry and Internal Medicine, Lausanne University Hospital, Lausanne, Switzerland.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Zins</LastName><ForeName>Marie</ForeName><Initials>M</Initials><AffiliationInfo><Affiliation>Population-based Epidemiological Cohorts Unit, INSERM UMS 11, Villejuif, France; Paris Descartes University, Paris, France.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Kawachi</LastName><ForeName>Ichiro</ForeName><Initials>I</Initials><AffiliationInfo><Affiliation>Harvard T H Chan School of Public Health, Boston MA, USA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Steptoe</LastName><ForeName>Andrew</ForeName><Initials>A</Initials><AffiliationInfo><Affiliation>University College London, Department of Epidemiology and Public Health, London, UK.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Mackenbach</LastName><ForeName>Johan P</ForeName><Initials>JP</Initials><AffiliationInfo><Affiliation>Department of Public Health, Erasmus University Medical Center, Rotterdam, Netherlands.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Vineis</LastName><ForeName>Paolo</ForeName><Initials>P</Initials><AffiliationInfo><Affiliation>MRC-PHE Centre for Environment and Health, School of Public Health, Department of Epidemiology and Biostatistics, Imperial College London, London, UK.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Kivimäki</LastName><ForeName>Mika</ForeName><Initials>M</Initials><AffiliationInfo><Affiliation>University College London, Department of Epidemiology and Public Health, London, UK; Clinicum, Faculty of Medicine, University of Helsinki, Finland.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><CollectiveName>LIFEPATH consortium</CollectiveName></Author></AuthorList><Language>eng</Language><GrantList CompleteYN="Y"><Grant><GrantID>MR/K013351/1</GrantID><Agency>Medical Research Council</Agency><Country>United Kingdom</Country></Grant></GrantList><PublicationTypeList><PublicationType UI="D016428">Journal Article</PublicationType></PublicationTypeList><ArticleDate DateType="Electronic"><Year>2017</Year><Month>02</Month><Day>01</Day></ArticleDate></Article><MedlineJournalInfo><Country>England</Country><MedlineTA>Lancet</MedlineTA><NlmUniqueID>2985213R</NlmUniqueID><ISSNLinking>0140-6736</ISSNLinking></MedlineJournalInfo><CommentsCorrectionsList><CommentsCorrections RefType="Cites"><RefSource>Lancet. 2013 Jul 6;382(9886):57-64</RefSource><PMID Version="1">23683599</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>N Engl J Med. 2010 Dec 2;363(23):2211-9</RefSource><PMID Version="1">21121834</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Stat Med. 2002 Aug 15;21(15):2175-97</RefSource><PMID Version="1">12210632</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Lancet. 2012 Dec 15;380(9859):2224-60</RefSource><PMID 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ValidYN="Y"><LastName>Avendano</LastName><ForeName>Mauricio</ForeName><Initials>M</Initials></Investigator><Investigator ValidYN="Y"><LastName>Barros</LastName><ForeName>Henrique</ForeName><Initials>H</Initials></Investigator><Investigator ValidYN="Y"><LastName>Bochud</LastName><ForeName>Murielle</ForeName><Initials>M</Initials></Investigator><Investigator ValidYN="Y"><LastName>Carmeli</LastName><ForeName>Cristian</ForeName><Initials>C</Initials></Investigator><Investigator ValidYN="Y"><LastName>Carra</LastName><ForeName>Luca</ForeName><Initials>L</Initials></Investigator><Investigator ValidYN="Y"><LastName>Castagné</LastName><ForeName>Raphaele</ForeName><Initials>R</Initials></Investigator><Investigator ValidYN="Y"><LastName>Chadeau-Hyam</LastName><ForeName>Marc</ForeName><Initials>M</Initials></Investigator><Investigator ValidYN="Y"><LastName>Clavel-Chapelon</LastName><ForeName>Françoise</ForeName><Initials>F</Initials></Investigator><Investigator ValidYN="Y"><LastName>Costa</LastName><ForeName>Giuseppe</ForeName><Initials>G</Initials></Investigator><Investigator ValidYN="Y"><LastName>Courtin</LastName><ForeName>Emilie</ForeName><Initials>E</Initials></Investigator><Investigator ValidYN="Y"><LastName>Delpierre</LastName><ForeName>Cyrille</ForeName><Initials>C</Initials></Investigator><Investigator ValidYN="Y"><LastName>D'Errico</LastName><ForeName>Angelo</ForeName><Initials>A</Initials></Investigator><Investigator ValidYN="Y"><LastName>Dugué</LastName><ForeName>Pierre-Antoine</ForeName><Initials>PA</Initials></Investigator><Investigator ValidYN="Y"><LastName>Elliott</LastName><ForeName>Paul</ForeName><Initials>P</Initials></Investigator><Investigator ValidYN="Y"><LastName>Fraga</LastName><ForeName>Silvia</ForeName><Initials>S</Initials></Investigator><Investigator ValidYN="Y"><LastName>Gares</LastName><ForeName>Valérie</ForeName><Initials>V</Initials></Investigator><Investigator ValidYN="Y"><LastName>Giles</LastName><ForeName>Graham</ForeName><Initials>G</Initials></Investigator><Investigator ValidYN="Y"><LastName>Goldberg</LastName><ForeName>Marcel</ForeName><Initials>M</Initials></Investigator><Investigator ValidYN="Y"><LastName>Greco</LastName><ForeName>Dario</ForeName><Initials>D</Initials></Investigator><Investigator ValidYN="Y"><LastName>Hodge</LastName><ForeName>Allison</ForeName><Initials>A</Initials></Investigator><Investigator ValidYN="Y"><LastName>Irving</LastName><ForeName>Michelle Kelly</ForeName><Initials>MK</Initials></Investigator><Investigator ValidYN="Y"><LastName>Karisola</LastName><ForeName>Piia</ForeName><Initials>P</Initials></Investigator><Investigator ValidYN="Y"><LastName>Kivimäki</LastName><ForeName>Mika</ForeName><Initials>M</Initials></Investigator><Investigator ValidYN="Y"><LastName>Krogh</LastName><ForeName>Vittorio</ForeName><Initials>V</Initials></Investigator><Investigator ValidYN="Y"><LastName>Lang</LastName><ForeName>Thierry</ForeName><Initials>T</Initials></Investigator><Investigator ValidYN="Y"><LastName>Layte</LastName><ForeName>Richard</ForeName><Initials>R</Initials></Investigator><Investigator ValidYN="Y"><LastName>Lepage</LastName><ForeName>Benoit</ForeName><Initials>B</Initials></Investigator><Investigator ValidYN="Y"><LastName>Mackenbach</LastName><ForeName>Johan</ForeName><Initials>J</Initials></Investigator><Investigator ValidYN="Y"><LastName>Marmot</LastName><ForeName>Michael</ForeName><Initials>M</Initials></Investigator><Investigator ValidYN="Y"><LastName>McCrory</LastName><ForeName>Cathal</ForeName><Initials>C</Initials></Investigator><Investigator ValidYN="Y"><LastName>Milne</LastName><ForeName>Roger</ForeName><Initials>R</Initials></Investigator><Investigator ValidYN="Y"><LastName>Muennig</LastName><ForeName>Peter</ForeName><Initials>P</Initials></Investigator><Investigator ValidYN="Y"><LastName>Nusselder</LastName><ForeName>Wilma</ForeName><Initials>W</Initials></Investigator><Investigator ValidYN="Y"><LastName>Panico</LastName><ForeName>Salvatore</ForeName><Initials>S</Initials></Investigator><Investigator ValidYN="Y"><LastName>Petrovic</LastName><ForeName>Dusan</ForeName><Initials>D</Initials></Investigator><Investigator ValidYN="Y"><LastName>Polidoro</LastName><ForeName>Silvia</ForeName><Initials>S</Initials></Investigator><Investigator ValidYN="Y"><LastName>Preisig</LastName><ForeName>Martin</ForeName><Initials>M</Initials></Investigator><Investigator ValidYN="Y"><LastName>Raitakari</LastName><ForeName>Olli</ForeName><Initials>O</Initials></Investigator><Investigator ValidYN="Y"><LastName>Ribeiro</LastName><ForeName>Ana Isabel</ForeName><Initials>AI</Initials></Investigator><Investigator ValidYN="Y"><LastName>Ribeiro</LastName><ForeName>Ana Isabel</ForeName><Initials>AI</Initials></Investigator><Investigator ValidYN="Y"><LastName>Ricceri</LastName><ForeName>Fulvio</ForeName><Initials>F</Initials></Investigator><Investigator ValidYN="Y"><LastName>Robinson</LastName><ForeName>Oliver</ForeName><Initials>O</Initials></Investigator><Investigator ValidYN="Y"><LastName>Valverde</LastName><ForeName>Jose Rubio</ForeName><Initials>JR</Initials></Investigator><Investigator ValidYN="Y"><LastName>Sacerdote</LastName><ForeName>Carlotta</ForeName><Initials>C</Initials></Investigator><Investigator ValidYN="Y"><LastName>Satolli</LastName><ForeName>Roberto</ForeName><Initials>R</Initials></Investigator><Investigator ValidYN="Y"><LastName>Severi</LastName><ForeName>Gianluca</ForeName><Initials>G</Initials></Investigator><Investigator ValidYN="Y"><LastName>Shipley</LastName><ForeName>Martin J</ForeName><Initials>MJ</Initials></Investigator><Investigator ValidYN="Y"><LastName>Stringhini</LastName><ForeName>Silvia</ForeName><Initials>S</Initials></Investigator><Investigator ValidYN="Y"><LastName>Tumino</LastName><ForeName>Rosario</ForeName><Initials>R</Initials></Investigator><Investigator ValidYN="Y"><LastName>Vineis</LastName><ForeName>Paolo</ForeName><Initials>P</Initials></Investigator><Investigator ValidYN="Y"><LastName>Vollenweider</LastName><ForeName>Peter</ForeName><Initials>P</Initials></Investigator><Investigator ValidYN="Y"><LastName>Zins</LastName><ForeName>Marie</ForeName><Initials>M</Initials></Investigator></InvestigatorList></MedlineCitation><PubmedData><History><PubMedPubDate PubStatus="received"><Year>2016</Year><Month>07</Month><Day>05</Day></PubMedPubDate><PubMedPubDate PubStatus="revised"><Year>2016</Year><Month>10</Month><Day>05</Day></PubMedPubDate><PubMedPubDate PubStatus="accepted"><Year>2016</Year><Month>11</Month><Day>01</Day></PubMedPubDate><PubMedPubDate PubStatus="pubmed"><Year>2017</Year><Month>2</Month><Day>6</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="medline"><Year>2017</Year><Month>2</Month><Day>6</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="entrez"><Year>2017</Year><Month>2</Month><Day>5</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate></History><PublicationStatus>ppublish</PublicationStatus><ArticleIdList><ArticleId IdType="pubmed">28159391</ArticleId><ArticleId IdType="pii">S0140-6736(16)32380-7</ArticleId><ArticleId IdType="doi">10.1016/S0140-6736(16)32380-7</ArticleId><ArticleId IdType="pmc">PMC5368415</ArticleId></ArticleIdList></PubmedData></pubmed><affiliations><list><country><li>Australie</li><li>Finlande</li><li>France</li><li>Irlande (pays)</li><li>Italie</li><li>Pays-Bas</li><li>Portugal</li><li>Royaume-Uni</li><li>Suisse</li><li>États-Unis</li></country><region><li>Angleterre</li><li>Canton de Vaud</li><li>Grand Londres</li><li>Hollande-Méridionale</li><li>Lombardie</li><li>Midi-Pyrénées</li><li>Occitanie (région 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Lasserre</name><name sortKey="Preisig, Martin" sort="Preisig, Martin" uniqKey="Preisig M" first="Martin" last="Preisig">Martin Preisig</name><name sortKey="Vollenweider, Peter" sort="Vollenweider, Peter" uniqKey="Vollenweider P" first="Peter" last="Vollenweider">Peter Vollenweider</name></country><country name="Finlande"><region name="Uusimaa"><name sortKey="Jokela, Markus" sort="Jokela, Markus" uniqKey="Jokela M" first="Markus" last="Jokela">Markus Jokela</name></region><name sortKey="Kivim Ki, Mika" sort="Kivim Ki, Mika" uniqKey="Kivim Ki M" first="Mika" last="Kivim Ki">Mika Kivim Ki</name></country><country name="États-Unis"><noRegion><name sortKey="Avenda O, Mauricio" sort="Avenda O, Mauricio" uniqKey="Avenda O M" first="Mauricio" last="Avenda O">Mauricio Avenda O</name></noRegion><name sortKey="Kawachi, Ichiro" sort="Kawachi, Ichiro" uniqKey="Kawachi I" first="Ichiro" last="Kawachi">Ichiro Kawachi</name><name sortKey="Muennig, Peter" sort="Muennig, Peter" uniqKey="Muennig P" first="Peter" last="Muennig">Peter Muennig</name></country><country name="Royaume-Uni"><region name="Angleterre"><name sortKey="Guida, Florence" sort="Guida, Florence" uniqKey="Guida F" first="Florence" last="Guida">Florence Guida</name></region><name sortKey="Chadeau Hyam, Marc" sort="Chadeau Hyam, Marc" uniqKey="Chadeau Hyam M" first="Marc" last="Chadeau-Hyam">Marc Chadeau-Hyam</name><name sortKey="Marmot, Michael G" sort="Marmot, Michael G" uniqKey="Marmot M" first="Michael G" last="Marmot">Michael G. Marmot</name><name sortKey="Shipley, Martin J" sort="Shipley, Martin J" uniqKey="Shipley M" first="Martin J" last="Shipley">Martin J. Shipley</name><name sortKey="Steptoe, Andrew" sort="Steptoe, Andrew" uniqKey="Steptoe A" first="Andrew" last="Steptoe">Andrew Steptoe</name><name sortKey="Vineis, Paolo" sort="Vineis, Paolo" uniqKey="Vineis P" first="Paolo" last="Vineis">Paolo Vineis</name></country><country name="Italie"><noRegion><name sortKey="Ricceri, Fulvio" sort="Ricceri, Fulvio" uniqKey="Ricceri F" first="Fulvio" last="Ricceri">Fulvio Ricceri</name></noRegion><name sortKey="Costa, Giuseppe" sort="Costa, Giuseppe" uniqKey="Costa G" first="Giuseppe" last="Costa">Giuseppe Costa</name><name sortKey="D Errico, Angelo" sort="D Errico, Angelo" uniqKey="D Errico A" first="Angelo" last="D'Errico">Angelo D'Errico</name><name sortKey="Krogh, Vittorio" sort="Krogh, Vittorio" uniqKey="Krogh V" first="Vittorio" last="Krogh">Vittorio Krogh</name></country><country name="Portugal"><noRegion><name sortKey="Barros, Henrique" sort="Barros, Henrique" uniqKey="Barros H" first="Henrique" last="Barros">Henrique Barros</name></noRegion><name sortKey="Fraga, Silvia" sort="Fraga, Silvia" uniqKey="Fraga S" first="Silvia" last="Fraga">Silvia Fraga</name></country><country name="France"><noRegion><name sortKey="Clavel Chapelon, Francoise" sort="Clavel Chapelon, Francoise" uniqKey="Clavel Chapelon F" first="Françoise" last="Clavel-Chapelon">Françoise Clavel-Chapelon</name></noRegion><name sortKey="Delpierre, Cyrille" sort="Delpierre, Cyrille" uniqKey="Delpierre C" first="Cyrille" last="Delpierre">Cyrille Delpierre</name><name sortKey="Goldberg, Marcel" sort="Goldberg, Marcel" uniqKey="Goldberg M" first="Marcel" last="Goldberg">Marcel Goldberg</name><name sortKey="Kelly Irving, Michelle" sort="Kelly Irving, Michelle" uniqKey="Kelly Irving M" first="Michelle" last="Kelly-Irving">Michelle Kelly-Irving</name><name sortKey="Zins, Marie" sort="Zins, Marie" uniqKey="Zins M" first="Marie" last="Zins">Marie Zins</name></country><country name="Australie"><noRegion><name sortKey="Giles, Graham G" sort="Giles, Graham G" uniqKey="Giles G" first="Graham G" last="Giles">Graham G. Giles</name></noRegion></country><country name="Irlande (pays)"><noRegion><name sortKey="Layte, Richard" sort="Layte, Richard" uniqKey="Layte R" first="Richard" last="Layte">Richard Layte</name></noRegion></country><country name="Pays-Bas"><region name="Hollande-Méridionale"><name sortKey="Mackenbach, Johan P" sort="Mackenbach, Johan P" uniqKey="Mackenbach J" first="Johan P" last="Mackenbach">Johan P. Mackenbach</name></region></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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